… derivatives from 2000 to 2011. In 2013, Jain and coauthors [56] reviewed the multifarious
applications of various thiazolidine-2,4-dione derivatives… -amylase and urease inhibitors. In this …

… for novel antitumor GLS1 inhibitors with higher potency, we designed a series of WA derivatives
… of substituents derived from small molecule GLS1 inhibitors via different linkers (Fig.á2). …

… of the inhibitors in the allosteric pocket (Figure 2b). Inspired by this discovery, we hypothesized
that rationally designed GAC inhibitors would form polar interactions with the P3 hotspot. …

… in vitro and cellular glutaminase-inhibiting activity. In summary, we discovered a new
glutaminase inhibitor with an … (37) A novel class of thiazolidine-2,4-dione-derived glutaminase …

… In summary, a novel series of thiazolidine-2,4-dione derivatives were designed,
synthesized, and evaluated as glutaminase inhibitors in this research. These potent analogues …

… developing glutaminase inhibitors as anticancer agents. This review paper described the
current understanding of … Thiazolidine-2,4-dione derivatives KGA 선택적 glutaminase 억제제인 …

… Furthermore, we highlight the glutaminase inhibitor based metabolic therapy strategy and …
Yeh et al. reported a class of thiazolidine-2,4-dione compounds targeting both GLS1 and GLS2…

… remain the main trend for future research on allosteric inhibitors. However, it is … thiazolidine-2,
4-dione scaffold compounds for the development of GLS1 allosteric inhibitors with novel …

… glutaminase inhibitors listed in Figure 1 have been met with major obstacles and generally
poor outcomes. The active site KGA inhibitors, … selectivity against liver type glutaminase (LGA) …

… lead compounds from other classes of inhibitors that target glutaminase enzymes, many of …
Thiazolidine-2,4-dione derivatives [77] possess unique structures from the previous classes of …